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Michael McIsaac, MS, MS, CSCS

Zinc: Function and Deficiencies

Zinc (Zn) is a micronutrient and essential cofactor/metal in many enzymes to include alkaline phosphatase, carbonic dehydratase, and polymerases and is obligatory for cell division and DNA synthesis (Crook, 2011). Deficiencies in Zn can cause several maladies such as increased risk of infections, infertility, impaired brain development, dermatitis, alopecia, low testosterone, and impaired smell/taste (Crook, […]

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Potassium: Function and Deficiencies

Potassium (K) is a micronutrient, which is a constituent of a larger family of electrolytes to include phosphorus (P), chloride (Cl), calcium (Ca), and sodium (Na) (Gropper, Smith, & Carr, 2018). When in balanced concentrations, electrolytes facilitate nerve conduction, movement of nutrients within a cell, pH balance, and fluid balance (Fluid and Electrolyte Balance, 2018). […]

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Processed Foods, Cardiovascular Disease, and Insulin Resistance

Excessive consumption of processed foods is a dominant trend in North America in which 70% of calories are derived from refined carbohydrates to include alcohol, vegetable oils, and sugar (Ilich, Kelly, Kim, & Spicer, 2014). Such refined sources (i.e., sugar sweetened beverages) have become linked to pathological conditions like cardiovascular disease (CVD) and insulin resistance/type 2 […]

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Electrolytes: Managing Hypertension

Hypertension, defined as resting blood pressure of ≥140/90,impacts over 29% of the adult American population and is a leading cause of renal disease, heart attack, and stroke (Gropper, Smith, and Carr, 2018). Sodium (Na) was one of the first micronutrients mechanistically linked with hypertension, and has since become a commonly understood factor in risk and […]

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Magnesium and Essential Functions

Magnesium (Mg) is a mineral found among a group of electrolytes to include potassium (K), sodium (Na), calcium (Ca), chloride (Cl), and phosphorus (P) (Maday, 2013). As an aggregate, electrolytes play a central role in balancing fluids, pH, transportation of nutrients and metabolites within the cell, and nerve conduction (Fluid and Electrolyte Balance, 2018). Considering […]

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Obesity, Atherosclerosis, and Phospholipase Enzyme 2 (PLA2)

Phospholipase enzyme 2 (PLA2) represents a group of enzymes found in the plasma. In particular, the primary enzymes behind phospholipid hydrolyzing processes is found amongst a sub-group known as secretory PLA2 (SPLA2) and have been associated with atherosclerosis (Garces et al., 2010). As such, the following will explore said enzymes in greater detail, other biomarkers […]

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Vitamin K2 Function

Vitamin K, a fat-soluble micronutrient, is found naturally in two forms to include phylloquinone (K1) and menaquinone (K2) (Gropper, Smith, & Carr, 2018). Said vitamin is widely recognized for its role in the synthesis of γ-carboxyglutamic acid (GLA); a residue necessary for blood clotting (Gropper et al., 2018). However, a lesser known function of vitamin […]

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Exercise, B6, and Oxidative Stress

Vitamin B6, also known as pyridoxine, is a water-soluble micronutrient functioning as a coenzyme in over 100 enzymes (Gropper, Smith, & Carr, 2018). However, its primary role is the metabolism of amino acids in addition to the synthesis of glucose, carnitine, sphingolipids, heme, nucleic acids, and neurotransmitters (Gropper et al., 2018). A lesser known role […]

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Pyridoxine (B6) and Most Digestible Food Sources

Pyridoxine (B6), is a micronutrient which serves as a coenzyme in over 100 enzymes (Grooper, Smith, & Carr, 2018). Furthermore, its primary role is found in the metabolism of glucose, carnitine, neurotransmitters, heme, nucleic acids, sphingolipids, and amino acids (Gropper et al., 2018). Considering B6’s integral role as a coenzyme and its involvement in energy/neurotransmitter […]

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B9 (Folate) Function and Deficiencies

B9, also known as folate, is a water-soluble micronutrient central to health and homeostasis (Sanvisens et al., 2017). Functions include the metabolism of nutrients such as choline, amino acids, pyrimidines, purines, DNA synthesis/repair, and cell division (Gropper, Smith, & Carr, 2018). As such, deficiencies in folate can lead to disruptions in said functions. As a […]

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