The liver has the capacity to manage toxic exposures via a layered process; phase 1 and phase 2. Such a process begins by the production of important enzymes (i.e., cytochrome p450) made within liver cells that help expedite the reduction/oxidation/hydrolysis reactions (i.e., phase 1) (Grant, 1991; Kim & Lee, 2006). Phase 2 is characterized by […]
Read MoreIt is thought that reactive oxygen species (ROS) are involved in many disease states to include arthritis, cancer, cardiovascular disease, diabetes, and Alzheimer’s disease (Duthie, 2003; Stockler-Pintos, Mafra, Farage, Boaventura, & Cozzolino, 2010). As such, maintaining optimal levels of anti-oxidants are critical in managing the destructive nature of ROS. Glutathione peroxidase (GSH-PX) is an example […]
Read MoreAntioxidants are substrates, which serve to protect a cell’s DNA, lipid membranes, and proteins from reactive oxygen species (ROS) (Duthie, 2003). As such, optimal levels of antioxidants are paramount in maintaining an organism’s health, performance, and longevity. Furthermore, ensuring that said substrate is adequately recycled for continued use is equal relevance (Gropper, Smith, & Carr, […]
Read MoreThe heart is a muscle (cardiac muscle) critical to sustaining life and homeostasis. Such an organ serves as a pump, which propels blood towards the lungs and other tissues via associated vasculature (Reisner & Reisner, 2017). Cardiac muscle is designed to work in almost near perpetuity; other muscles (i.e., skeletal) are not always required to […]
Read MoreCoQ10 is a nutrient whose production tends to become down-regulated by two main sources: genetic mutations involved in its synthesis (a primary deficiency) and statins, which inhibit an enzyme (hydroxymethylglutaryl coenzyme A) involved in the development of CoQ10 (considered a secondary deficiency) (Potgieter, Pretorius, & Pepper, 2013). Secondary deficiency is a common side-affect amongst individuals on […]
Read MoreMovement is the product of many systems working together in a highly coordinated and harmonious fashion. Such systems include the sensorimotor, musculoskeletal, and energy systems (Page, Lardner, & Frank, 2010). When functioning optimally, the coalescence of such systems can produce meaningful and effective motions, such as running. Over time, however, fatigue is expressed as a […]
Read MoreMultiple sclerosis (MS) is a disease characterized by inflammatory, demyelinating, and autoimmune events affecting more than 2 million people worldwide (Reich, Lucchinetti, & Calabresi, 2018).Brum, Comini-Frota, Vasconcelos, and Dias-Tosta (2014) stated that although the etiology of multiple sclerosis (MS) has not been clearly uncovered, there does exist environmental and genetic factors thought to manifest the […]
Read MoreOptimal vitamin D levels, as measured by 25-hydroxyvitamin D, remains to be somewhat equivocal, thereby affecting recommended oral doses of vitamin D3. Since research indicates the critical relationship of vitamin D to optimal health, it behooves one to consider the nuances and implications of recommending supplemental vitamin D to individuals. The following will explore the […]
Read MoreVitamin D3, also known as cholecalciferol, is the precursor/pre-vitamin to 1,25-(OH)2D; the active form within the body, known as calcitriol (Chaplin & Jablonski, 2013). Vitamin D3 can be derived from sun exposure as well as foods such as fatty fish (i.e., salmon and sardines), plants (i.e., shitake mushrooms), fortified foods (i.e., milk, yogurt, butter, cheese) […]
Read MorePost-rehabilitation (PR) clients require diligent and scrupulous program design. Extensive weakness and deconditioning are common traits among the aforementioned populace. PR clients are often seeing a medical professional, or have been recently discharged. Their injuries are usually resolved, but they are often not ready for the rigors of daily activity or work related tasks. Thus, […]
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